This course is designed to introduce students to a range of experimental techniques that are in routine use in a functioning biochemistry laboratory with the objective that they can understand basic principles behind these techniques and are able to understand their applicability in their future research. Whenever possible, the course combines lectures illustrating the scientific principles underlying a particular technique with the demonstration of the methodology in the laboratory.
The field of Molecular and Cellular Biology has given scientists unprecedented control over species manipulation and development. This course will have an in-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins. In this course, we will discuss the nature of genes and chromosomes (the repositories of genetic information) and the mechanics of DNA synthesis and genome replication, followed by discussions on repair, recombination and transposition. We will also discuss the pathways of gene expression (transcription, RNA processing, and translation) and the mechanisms of regulating these pathways, with special emphasis on transcriptional control. Latest literature on these topics will be covered.
This course will focus on the cellular biochemistry of higher organisms: mechanisms of cellular communication, intracellular signaling, cell growth and oncogenic transformation. During the course, two basic cellular structures will be discussed: membrane and mitochondria, two important key players in cell signaling and cell death. Concepts like cell signaling, cell cycle, oxidative stress and cell death will be reviewed. The course will end with an introductory lecture on stem cell biology. Recent experimental findings and new approaches used to investigate how cells work will be emphasized. Students will also be taught how to explore the cell biology literature and to critically evaluate scientific publications in some of the topics.
This course is designed to prepare students in learning advanced cellular biochemistry and metabolism under physiological and pathophysiological conditions for successful careers in academia and biotechnology industries. The course also provides enhanced education opportunities for students who wish to extend their knowledge, experience, and opportunities as independent scientists in academic research at universities, biotechnology and pharmaceutical industries, health/biomedical science management or teaching. In this course, advanced cellular biochemistry will be explained to signify the importance of metabolism in normal physiology and pathophysiological conditions. Faculty lectures and students reports will focus on these.
Dysfunction of the human brain can produce a wide variety of neurological and psychiatric illnesses. Over the past decades, neuroscientists have begun to unravel the basic underlying mechanisms of a number of important diseases of the nervous system, at the cellular, molecular and genetic levels. None of these disorders are completely understood, and, perhaps more importantly, none are yet susceptible to either total prevention or cure, so that these conditions remain among the most important health problems of our society. These lectures are designed to familiarize the students with basic information about two important neurological disorders Alzheimer’s disease, Parkinson’s disease, Huntington's disease, and Prion diseases, focusing on a relatively brief clinical description of the condition and a more in depth discussion on current hypotheses about the mechanisms underlying these diseases.
This course will provide students the chance to rotate through the laboratory of a potential supervisor to learn about the various projects in progress in that laboratory with emphasis on acquainting themselves with the type of research work and techniques being used. Regular attendance (one hour per week) and active participation of the student in observing and learning about these projects is of great importance. The students should study the literature provided by their respective supervisors and familiarize themselves with the research activities being carried out in the laboratory chosen by them.
This course covers the fundamentals of Molecular Biology. The first part introduced the students to the fundamentals of DNA and RNA and how they are used to make proteins. This part of the course consists of the structure/function of nucleic acids, how DNA is assembled into chromatin, replicated, transcribed into RNA, and translated into proteins. Alongside, students are introduced to the concept of genes and how gene expression is regulated, followed by how this process differs in prokaryotes that do not have a nucleus, and eukaryotes, organisms with nucleus. The second part of the course introduces the students to how problems with DNA replication and expression can lead to "errors" that result in disease and how one can study DNA/RNA/proteins in "Molecular Medicine". Thus, this part of the course discusses mutations, how mutations are repaired in the body, and how changes in the structure of DNA can be introduced via specific recombination systems to create diversity. This is followed by a series of lectures on how one can study DNA, RNA, and proteins at the molecular level to study and diagnose diseases and even use these methods for cloning and creating new types of DNA molecules. The course ends with a lecture on how the body uses RNA (RNAi) to control gene expression, a new area that is revolutionizing Molecular Biology.
This course covers foundational concepts in general chemistry to enable students to understand the physiology and biochemistry of the human body in health and disease which they will study in subsequent courses. During the Chemistry practicals, students will be introduced to the principles of safe laboratory practice and will become familiar with the equipment commonly used in the chemistry laboratory. Students will become familiar with scientific writing in terms of completing laboratory reports.
This course is divided into three parts. During the first part, students will be introduced to the different classes of the basic molecules of life (amino acids, proteins, carbohydrates, nucleic acids and lipids) the differences in their structure and function and how these form into biochemical complex compounds. The second part will discuss the biology of cells of higher organisms: the structure and function of cellular membranes and organelles; the chromatin structure and genes; the cytoskeleton, the extracellular matrix and cell movements; the cell death and cell junctions. Finally, the third part will introduce the concept of nutrition describing the importance of vitamins and minerals. In addition, cellular physiology areas such as pH, buffers and enzyme mechanisms will also be discussed.
This course covers cellular communication and metabolism for successful progress in organ system. The course will provide basic knowledge of cellular communication and receptor based cell signalling by hormones and intracellular signalling mechanisms which control cellular growth and metabolism. The course will also introduce you with basic concept of cellular metabolism (anabolism i.e. synthesis of biomolecules and catabolism i.e. breakdown of biomolecules) in different compartments of cells using carbohydrate (sugars), nucleotides, lipids, and amino acid metabolism as examples. You will also learn about the metabolism and excretion of the important metabolic waste products such as urea and bilirubin. Since liver is a central organ for nutrient metabolism, synthesis, storage and secretion/excretion of metabolic products, you will also learn many functions of the liver in maintaining metabolic homeostasis. During this Course, the students will learn in details, the processes by which cells metabolize their nutrients (carbohydrates, lipids, amino acids and nucleotides). They will also learn how cells are communicating with each other and how their metabolism are controlled and regulated.
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